Fig. 7. A scheme to illustrate spatial relationships among VGCC, TRP channel, RyR and SK channel and Zn²⁺ action in different Ca²⁺ chelator condion. Intracellular Ca²⁺ sources are extracellular Ca²⁺ influx via VGCC, TRP channel and Ca²⁺-induced Ca²⁺ release from RyR/IP3R in ER. Ca²⁺ concentration increases also induce the activation of TPRM channel amplifying cytosolic Ca²⁺ increases. EGTA condition, internal Ca²⁺ plays a key role in neuronal activity, and their blockades of Ca²⁺-related channels as a Ca²⁺ source and SK channel as a Ca²⁺ sensor act as an major factor in Zn²⁺-induced augmentation of neuronal activity. BAPTA condition, internal Ca²⁺ action is excluded, and thus KA channel acts as key factor in Zn²⁺-induced alteration of neuronal activity (thick arrow, increase; thin arrow, normal function; broken arrow, inhibition; gray channel & arrow, nonfunctional).

Exp Neurobiol 2019;28:578~592 https://doi.org/10.5607/en.2019.28.5.578

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