Differences in [123I]FP-CIT BPND
| Drug | Dose (mg/kg) | Striatum | Midbrain | ||||
|---|---|---|---|---|---|---|---|
| BPND | % Difference | p | BPND | % Difference | p | ||
| VEH | - | 1.64±0.13 | - | - | 1.69±0.32 | - | - |
| BUP | 20 | 1.37±0.22 | −16.50±13.41 | 0.3954 | 1.16±0.16 | −31.57±9.26 | 0.2165 |
| 100 | 0.72±0.08 | −56.29±4.59 | 0.0006 | 0.79±0.12 | −53.08±7.21 | 0.0376 | |
| HAL | 1 | 1.22±0.09 | −25.29±5.60 | 0.0749 | 0.70±0.12 | −58.74±7.38 | 0.0041 |
| 7 | 1.60±0.06 | −2.27±3.65 | 0.9797 | 0.85±0.05 | −49.64±3.13 | 0.0215 | |
| CLZ | 10 | 1.95±0.20 | 18.85±12.00 | 0.2257 | 1.04±0.11 | −38.60±6.53 | 0.0668 |
| 54 | 2.27±0.13 | 38.64±7.87 | 0.0061 | 1.01±0.05 | −40.38±2.76 | 0.0676 | |
Values are the mean±SEM. VEH, vehicle; BUP, bupropion; HAL, haloperidol; CLZ, clozapine.