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Fig. 1. Group mean (n=5 per drug and dose condition) BPND parametric images comparing changes in [123I]FP-CIT BPND in the striatum (A) and midbrain (B) after treatment with BUP, HAL and CLZ. These changes are also summarized in graphs (C). VEH, BUP, HAL and CLZ represent the vehicle-, bupropion-, haloperidol- and clozapine-treated groups. The low and high doses of HAL, CLZ and BUP were 1 and 7 mg/kg body weight, 10 and 54 mg/kg body weight, and 20 and 100 mg/kg body weight, respectively. Values are the meanĀ±SEM. White lines overlaid on the SPECT images of the striatum (A) and midbrain (B) for the vehicle-treated group show the margin of each region.
Exp Neurobiol 2019;28:602~611
© Exp Neurobiol