Fig. 7. Proposed mechanisms for the role of LGR5 and hnRNP in human meningioma and pituitary adenoma. The left panel shows the OFF state of the canonical Wnt/β-catenin signaling. R-spondin-mediated activation of LGR5 promotes Wnt/β-catenin signaling (right panel). This process leads to stabilization of β-catenin, which interacts with TCF/LEF proteins in the nucleus and together they activate Wnt target genes. We suggest that activation of Wnt target genes may also affect activation of the hnRNP family. This process may lead to hyperactivation of alternative gene transcription, splicing, and post-transcriptional modification of pre-mRNA processing in human meningioma and pituitary adenoma.
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