Fig. 4. Three-dimensional structures of ANO1. (A) The secondary structure of ANO1 was shown with ribbon presentation method, colored by yellow (left subunit of dimer), cyan (right subunit of dimer), green (Ca2+ ions), and red (EF-hand like region, 285~297 residue numbers), respectively. (B) View of dimer structure of ANO1 from extracellular side. (C) View of structure from the membrane looking towards EF-hand like region (colored by red) and Ca2+ binding site (shown with greed colored Ca2+ ions), respectively. (D) Close-up view of EF-hand like region and Ca2+ binding site.
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