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Fig. 2AEffects of MK-801 administration on locomotor activity of mice in the open field test. Subject mice were administered with either MK-801 (0.1, 0.12, 0.15, 0.2 and 0.3 mg kg−1) or 0.9% NaCl thirty minutes prior to the experiment. Open field test was then performed for 25 minutes, measuring the distance moved () and its progression in a five-minute time bin (Fig. 2B) as parameters. Data were analyzed using a one-way ANOVA test and are expressed as the mean±S.E.M (n=10~15 mice per group). *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 vs. vehicle group as revealed by post hoc Tukey's multiple comparisons test.
Exp Neurobiol 2019;28:697~708
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