KEGG pathways which functional annotation clusters of down-regulated genes in group 4 versus 1 revealed

KEGG pathwayp-valueBenjaminiGenes
TNF signaling pathway5.5E-74.5E-5BCL3, CCL5, NFKBIA, TNFAIP3, ICAM1, NOD2, SOCS3
NOD-like receptor signaling pathway6.1E-41.6E-2CCL5, NKFBIA, TNFAIP3, NOD2
Epstein-Barr virus infection4.5E-41.8E-2NFKBIA, TNFAIP3, CDKN1A, ICAM1, HLA-DRB1
Influenza1.7E-32.7E-2CCL5, NFKBIA, ICAM1, HLA-DRB1, SOCS3
HTLV-1 infection6.6E-36.5E-2NFKBIA, CCND3, CDKN1A, ICAM1, HLA-DRB1
Cytokine-cytokine receptor interaction5.7E-36.4E-2CCL5, CCR7, CXCR4, IL10RA, IL13RA1
Chemokine signaling pathway1.8E-21.2E-1CCL5, CCR7, CXCR4, NFKBIA

Most of them are associated with proinflammatory cascades, of which down-regulation might suppress disease activity of MG.

Exp Neurobiol 2019;28:720~726
© Exp Neurobiol