An incidental observation using 18F-fluorodeoxyglucose positron emission tomography in mice, following unilateral common carotid artery occlusion (UCCAO). In our pilot evaluations, glucose uptake patterns were classified into two types after the operation. (A) An example of a mouse brain with symmetrical uptake despite right UCCAO. In most mice with the UCCAO operation, glucose uptake was symmetrical. (B) An example of a mouse brain with asymmetrical glucose uptake in the ischemic hemisphere (right side on the figure). In a subset of mice, glucose uptake was found to asymmetrically increase in the right hemisphere. (C) To determine the most appropriate time for viewing asymmetric glucose uptake, UCCAO-operated (n=3 per day) and sham-operated mice (n=1 per day) were examined at days 1, 4, 7, 10, 14, 21, and 28 after the operation. One of three UCCAO mice showed an increase in glucose uptake at 7 and 10 days, respectively. One of three UCCAO mice showed a decrease in glucose uptake at 28 days. Otherwise, symmetric glucose uptake patterns were shown. The seventh day was selected for further glucose uptake evaluations.