Experimental design for in vivo studies

Toxicity (n) BMD42-29 BMD42-2910 DMSO
4 mg/kg 20 mg/kg 100 mg/kg 4 mg/kg 20 mg/kg 100 mg/kg
Male 5 5 5 5 5 5 5
Female 5 5 5 5 5 5 5
Infectivity (n) Infected with PrP Sc Uninfected
BMD42-29 BMD42-2910 DMSO DMSO
5 mg/kg 20 mg/kg 5 mg/kg 20 mg/kg
Female (Total) 50 50 50 50 15 10
For 100 DPI 20 20 20 20 5
For 170 DPI 20 20 20 20 5
For survival 10 10 10 10 5 10
Exp Neurobiol 2020;29:93~105 https://doi.org/10.5607/en.2020.29.1.93
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