Inhibition of PrP^res amplification in ME7-infected mice treated with BMD42-29 or BMD42-2910. Effects of BMD42-29 and BMD42-2910 on PrP^res amplification in ME7-infected mice were analyzed. The infected mice were treated with 5 and 20 mg/kg of the compounds and DMSO. At 100 and 170 DPI, seventeen to nineteen mice per a group were euthanized, and their brain, spleen, and plasma were immunoblotted after PK treatment. Representative blots are shown per a group, with molecular mass markers indicated to the right of the blots (A). Individual PrP^res levels were shown by scatter plots (B). Each spot corresponds to band intensity/DMSO band intensity ×100. *p<0.05. **p<0.001. Survival durations of the eight to ten mice per a group infected with ME7 and treated with 20 (line) and 5 (dotted line) mg/kg per week of BMD42-29 (blue), BMD42-2910 (green) or DMSO (red line), and uninfected mice treated with DMSO (black line) are shown by Kaplan-Meier curves (C).