Docking model of α-pinene and 3-carene in BZD binding site of GABA_A receptor. Top and side views of GABA_A receptor homology model (a), the binding pose of zolpidem, flumazenil, and α-pinene (b). ECD, extracellular domain; TMD, transmembrane domain. GABA_A receptor shown by different chain color (c). Docking model of 3-carene interacting residues on GABA_A receptor (d). Various interactions between 3-carene and surrounding residues of GABA_A receptor (e). (a,b) from Yang et al., 2014, Mol. Pharm., (c-e) from Woo et al., 2019, Exp. Neurobiol.