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Fig. 4.

Docking model of α-pinene and 3-carene in BZD binding site of GABAA receptor. Top and side views of GABAA receptor homology model (a), the binding pose of zolpidem, flumazenil, and α-pinene (b). ECD, extracellular domain; TMD, transmembrane domain. GABAA receptor shown by different chain color (c). Docking model of 3-carene interacting residues on GABAA receptor (d). Various interactions between 3-carene and surrounding residues of GABAA receptor (e). (a,b) from Yang et al., 2014, Mol. Pharm., (c-e) from Woo et al., 2019, Exp. Neurobiol.

Exp Neurobiol 2020;29:120~129
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