KCC2 knockdown rescues anxiety-like behaviors in MIR137 cKO mice. (A-B) In the open field test, MIR137 cKO mice with sh-KCC2 treatment dramatically increased the number of entries (A) and time spent (B) in the central zone (n=12~13 mice per group, **p<0.01, *p<0.05). (C, D) In the light/dark box test, sh-KCC2-treated mice demonstrated improved entries (C) and time spent (D) in light box (n=12~13 mice per group, **p<0.01, *p<0.05).