Fig. 7. Schematic model for physiological roles of ERK-dependent phosphorylation of NeuroD1. NeuroD1 proteins heterodimerize with E47, translocate to the nuclear compartment, and transactivate downstream target genes. Consequently, NeuroD1 induces cell cycle exit, neuronal differentiation, and neurite outgrowth. ERK-dependent phosphorylation at S274 facilitates ubiquitination and proteasomal degradation of NeuroD1. By negatively regulating NeuroD1, Erk maintains the progenitor pools at mid-stage brain development and promotes glial cell differentiation of progenitor cells at the expense of neurogenesis at late-stage brain development.
© Exp Neurobiol
