Experimental Neurobiology

IPN causative genes and the inheritance pattern

Type	Dominant	Recessive
Demyelinating type	PMP22, PMP2, MPZ, LITAF, FBLN5, EGR2, NEFL*	MPZ, NEFL, EGR2, GDAP1, MTMR2, SH3TC2, NDRG1, PRX, FGD4, SBF1, SBF2, FIG4, CTDP1, SURF1, ADCY6, CNTNAP1, HK1
Axonal type	MFN2, GDAP1, LRSAM1, MPZ*, NEFH, KIF5A, ATP1A1, VCP, TFG, DHTKD1, TUBB3, NAGLU, DCAF8, DGAT2, MORC2, HSPB1, HSPB3, HSPB8, GARS, AARS, HARS, MARS, DYNC1H1, BICD2, REEP1, BSCL2, SETX, SLC5A7, MYH14, TRPV4, RAB7	LMNA, PNKP, TRIM2, SPG11, MME, MCM3AP, SLC25A46, SCO2, MPV17, LRSAM1*, C12orf65, IGHMBP2, SIGMAR1, VRK1, ATP7A, UBA1, GLE1, LAS1L
Intermediate type (mixed type)	NEFL, MPZ, GJB1, YARS, INF2, DRP2, DNM2, GNB4, PDK3	GDAP1*, COX6A1, PLEKHG5, KARS, AIFM1, PRPS1
Incidence	> 95%	< 5%

^*Mutations in the gene cause dominant or recessive inheritance.