Strategies to improve therapeutic efficacy for IPN treatment

Type Category Strategy
Viral delivery Toxicity Reduction of genotoxicity using specific target sequence to avoid activation of proto-oncogene or using regulatory machinery for transgene expression
Efficiency Enhancement of viral tropism specific to peripheral nervous system
Non-viral delivery Stability Development of enhanced vehicle to increase the stability of oligonucleotides
Chemical modification of oligonucleotide to increase the stability
Efficiency Development of novel chemical composition or peptide to enhance cell uptake and to facilitate endolysosomal escape or nuclear translocation
Specificity Isolation of novel receptors or membrane compositions in Schwann cell or axon
Development of novel ligands specific to peripheral nervous system
Exp Neurobiol 2020;29:177~188
© Exp Neurobiol