Differences in clinical and chemical variables in subjects with higher and lower lactate-to-pyruvate ratios in the affected group
| Higher ratio (>25) (n=16) | Lower ratio (≤25) (n=43) | t | df | p | ||||
|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | |||||
| Lactate | 28.47 | 15.96 | 16.56 | 6.77 | -2.89 | 17.05 | 0.0102 |
|
| Pyruvate | 0.83 | 0.47 | 1.20 | 0.41 | 2.91 | 57.00 | 0.0052 |
|
| Lactate-to-pyruvate ratio | 40.92 | 26.51 | 14.23 | 4.51 | -4.01 | 15.32 | 0.0011 |
|
| ADI-R | Social interaction | 20.50 | 4.23 | 17.86 | 6.86 | 0.07 | 57.00 | 0.1564 |
| Communication: verbal | 15.50 | 3.23 | 14.22 | 5.73 | -0.73 | 42.00 | 0.4701 | |
| Communication: nonverbal | 10.13 | 2.68 | 9.02 | 3.77 | 0.20 | 57.00 | 0.2891 | |
| Repetitive behavior | 6.56 | 3.20 | 5.19 | 2.88 | -1.58 | 57.00 | 0.1189 | |
| ADOS | Communication | 6.13 | 1.78 | 5.09 | 1.89 | -1.89 | 57.00 | 0.0633 |
| Social interaction | 9.81 | 1.68 | 9.44 | 2.61 | -0.53 | 57.00 | 0.6004 | |
| Play | 1.81 | 1.11 | 1.93 | 1.12 | 0.36 | 57.00 | 0.7204 | |
| Repetitive behavior | 1.06 | 1.00 | 1.30 | 1.44 | 0.61 | 57.00 | 0.5428 | |
| KEDI-WISC-R | 73.33 | 23.77 | 75.12 | 19.74 | 0.23 | 40.00 | 0.8187 | |
| K-Leiter-R | 69.17 | 18.54 | 73.77 | 15.48 | 0.57 | 17.00 | 0.5779 | |
| SCQ | 16.88 | 6.20 | 16.58 | 9.37 | -0.12 | 52.00 | 0.9083 | |
| SRS | 87.06 | 19.73 | 88.21 | 32.01 | 0.13 | 56.00 | 0.8938 | |
| Paternal age | 31.94 | 3.974 | 32.63 | 6.091 | 0.42 | 57.00 | 0.6762 | |
| Maternal age | 33.81 | 3.885 | 34.98 | 6.585 | 0.66 | 57.00 | 0.5198 | |
| Prenatal events (%) | 10 (62.50) | 17 (39.53) | χ2=2.47 | 1 | 0.1153 | |||
| Perinatal events (%) | 6 (37.50) | 11 (25.58) | χ2=0.81 | 1 | 0.3694 | |||
| mtDNA CNV | 162.50 | 44.05 | 164.09 | 42.38 | 0.13 | 57.00 | 0.8991 | |
| PGC-1α | 0.15 | 0.07 | 0.17 | 0.20 | 0.50 | 52.00 | 0.6210 | |
*p<0.05, **p<0.01.
ADI-R, Autism Diagnostic Interview-Revised; ADOS, Autism Diagnostic Observation Schedule; KEDI-WISC-R, Korean Educational Development Institute-Wechsler Intelligence Scale for Children-Revised; K-Leiter-R, Korean-Leiter International Performance scale - Revised; mtDNA CNV, mitochondrial DNA copy number variation; PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1-alpha methylation ratio; SCQ, Social Communication Questionnaire; SRS, Social Responsiveness Scale.