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Fig. 5. Protective effect of DEX on P7 hippocampal injury induced by a single dose of propofol. TUNEL staining in the hippocampal CA1 area of rodent pups. The protective effects of dexmedetomidine (DEX) were inhibited by yohimbine (Y). Neonatal rats were evaluated after 8 h exposure to 30 mg/kg propofol (P2 group), post-injection of 1, 10 or 20 μg/kg DEX (D1, D2 or D3 group), co-exposure to 1, 10, or 20 μg/kg DEX 1 h before 30 mg/kg propofol (D1/D2/D3+P2 group), and yohimbine 1 μg/kg 0.5 h before the similar injection regimen with DEX and propofol (Y+D1/D2/D3+P2 group), respectively. Data are means±SD from three independent experiments. ****p<0.0001 vs. the control group, ####p<0.0001 vs. P2 group, &p<0.05, &&&p<0.001 vs. D2/D3+P2 group.
Exp Neurobiol 2020;29:356~375
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