Fig. 1. Effects of MCH administration on depression- and anxiety-related behaviors in stressed rats. (A) Schematic representation of developing SPS and details of MCH administration. SPS was induced by immobilization (2 h), forced swim (20 min), rest (15 min), and ether anesthesia on day 1. Rats were left undisturbed after SPS. OFT and EPM tests were performed on day 11. An FST was conducted and animals were sacrificed on day 18. (B) Intranasal MCH treatment in rats. (C) Variations in body weight of rats over the course of 18 days. MCH and fluoxetine significantly induced weight loss in rats from day 10 compared with STR. Effects of MCH on depression- and anxiety-related behaviors in (D~G) OFT, (H~J) EPM test, and (K~M) FST in stressed rats. Data represent the means±SEM. ***p<0.001, **p<0.01, *p<0.05 vs. Nor group, ###p<0.001, ##p<0.01, #p<0.05 vs. STR group. SPS, single prolonged stress; OFT, open field test; EPM, elevated plus maze; FST, Forced swimming test; Nor, normal; STR, stress; Flu, fluoxetine.
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