Fig. 3. Rapamycin blocks the antidepressant-like and anxiolytic-like effects of MCH. Effects of MCH (18 μg/30 μl) administration on depression and anxiety behaviors in (A, B) OFT, (C~F) EPM test, and (G~I) FST in stressed rats. Pretreatment with the mTOR inhibitor rapamycin (110 μg/30 μl, intranasal) blocked the antidepressant and anxiolytic effects of MCH. Data represent the means±SEM. ***p<0.001, *p<0.05 vs. Nor group, ###p<0.001 vs. STR group, $$$p<0.001, $p<0.05 vs. MCH group. Nor, normal; STR, stress; Rapa, rapamycin; OFT, open field test; EPM, elevated plus maze; FST, forced swim test.
© Exp Neurobiol
