Animal studies of NETs in stroke
| Author, year | Species | Biomarkers | Method used in measurement of NETs | Results |
|---|---|---|---|---|
| Kang et al., 2020 [50] | Mice | H3Cit | Western Blot (ischemic cortex) and immunostaining (peri-infarct cortex) | Cortex of ischemic mice have shown higher amount of H3Cit+ neutrophils. Peri-infarct cortex was extensively labelled with H3Cit+ cells after 3 days |
| Kim et al., 2019 [51] | Rat | H3Cit | Immunofluorescence | The first H3Cit+ cells entry occurred at 12 hours after middle cerebral artery occlusion through leptomeninges |
| Perez-de-Puig et al., 2015 [24] | Mice | H3Cit | Immunofluorescence | H3Cit+ neutrophils found in perivascular spaces, cerebral parenchyma near blood vessels, lumen capillaries, and striatum |