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Fig. 2. The origin and function of Treg cells. CD4+CD25+FoxP3+Tregs mainly arise from progenitor cells in the bone marrow and develop in the thymus through the processes of positive and negative selection. CD4+CD25+FoxP3+Tregs can limit activation of effector T cells. Tregs are also able to change the polarization of microglia and suppress excessive expression of neuroinflammatory mediators by microglia.
Exp Neurobiol 2021;30:101~112
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