Fig. 2. The origin and function of Treg cells. CD4⁺CD25⁺FoxP3⁺Tregs mainly arise from progenitor cells in the bone marrow and develop in the thymus through the processes of positive and negative selection. CD4⁺CD25⁺FoxP3⁺Tregs can limit activation of effector T cells. Tregs are also able to change the polarization of microglia and suppress excessive expression of neuroinflammatory mediators by microglia.

Exp Neurobiol 2021;30:101~112 https://doi.org/10.5607/en20033

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