Fig. 10. Schematic summary of the key gene sets which presumably cause tumorigenesis of CN spheroids. CN-spheroids show upregulation of EGFR signaling, CSPG signaling, and Notch signaling, whereas eph-ephrin signaling is downregulated. CSPGs stimulate NSC survival through enhanced EGFR signaling. ERBB4 of Notch signaling is also function as oncogene. Eph-ephrin signaling, which is comprised with EPHB2, EPHB3 and EPHB4, are known as putative tumor suppressor genes. CHL1 is expressed and functions as a malignancy promoter in GBM cells.
© Exp Neurobiol
