Fig. 6. OA suppresses pyroptosis induced by OGD/R by regulating miR-186-5p and Ngb expression. (A, B) mRNA (A) and protein (B) expression levels of Ngb in neurons were evaluated as shown by qRT–PCR and western blotting. (C) Pyroptosis was detected by flow cytometry. (D) Alterations in IL-1β and IL-18 were determined by ELISA. (E) LDH release was modulated after OA treatment in OGD/R neurons. (F) Pyroptosis-related markers were examined by western blotting. The results are shown as the mean±SD. n=3 per group. *p<0.05, **p<0.01, ***p<0.001.
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