Fig. 7. The effect of OA treatment in MCAO/R mice. MCAO/R or sham surgery was performed in mice, and OA was administered to the MCAO/R+OA group. (A) TTC was utilized to detect the cerebral ischaemia area. (B) Quantification of infarct volume. (C) IL-1β and IL-18 levels were determined using ELISA. (D) LDH release. (E) Pyroptosis-related markers were evaluated by western blot assay. (F) miR-186-5p expression was examined by qRT-PCR. (G, H) mRNA (G) and protein (H) levels of Ngb were evaluated by qRT-PCR and western blotting, respectively. The results are shown as the mean±SD. n=6 per group. *p<0.05, **p<0.01, ***p<0.001.
© Exp Neurobiol