Fig. 1. Repeated hyperoxygenation treatment was required to produce antidepressive effects in CRST mice. (A) Experimental design. CRST mice were treated with 100% O2 (HO2) at 2 ATA for 1 h daily for 3, 7, or 14 days. CON (13), naïve control; CRST(16), CRST+HO23d (6), CRST+HO27d (15), and CRST+HO214d (15), CRST mice and CRST mice treated with HO2 for 3, 7, or 14 days. (n), number of animals for the indicated groups. The results of two independent sets of experiments were combined. (B, C) The percent time of social interaction in the two-choice field (B) of the sociability test (C) of the indicated groups. The fields with the social target and the non-target are indicated (B). (D, E) The immobility time in the TST (D) and FST (E) of the indicated groups. Mean±SEM. *,**difference between indicated group. *p<0.05, **p<0.01 (one-way ANOVA and Newman-Keuls post hoc test).
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