Fig. 2. Repeated and hyperbaric hyperoxygenation treatment in CRST mice produced antidepressive effects. (A) Experimental design. CRST mice were treated with HO2 (100% O2) at 2 ATA for 1 h daily for 14 days or imipramine (IMI; 20 mg/kg/day, i.p.) for 14 days. n=12~20 animals per group. (B) Body weight changes during the stress phase (days 1~14) and following hyperoxygenation treatment (days 15~28, shaded box) of the indicated groups. (C~E) The percent time of social interaction in the sociability test (C), and the immobility time in the TST (D) and FST (E) of the indicated groups. (F) Experimental design. CRST mice were treated with HO2 (100% O2) at 1.5 ATA or 2.0 ATA for 1 h daily for 14 days (CRST+HO2-1.5 and CRST+HO2-2.0, respectively) or imipramine for 14 days (CRST+IMI). IMI, 20 mg/kg/day, i.p. Behavioral tests were performed at post-stress days 15~21 (Exp #1) and at post-stress days 28~35 (Exp #2). n=10~14 animals per group. (G~J) Immobility time in the TST (G, I) and FST (H, J) of the CON, CRST, CRST+HO2-1.5, CRST+HO2-2.0, and CRST+IMI groups at post-stress days 15~21 and at post-stress days 28~35. Mean±SEM. *,**difference between indicated group. *p<0.05, **p<0.01 (one-way ANOVA and Newman-Keuls post hoc test).
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