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Fig. 3. Three critical legs to high-performance model organism-based studies of rare neurological diseases. For successful identification of potentially pathogenic variants causative of rare neurological diseases, an interactive collaboration is mandatory among clinicians responsible for initial identification of patients, bioinformatics specialists handling multi-omics and knowledgebase datasets and research scientists with expertise in model organisms or systems, including invertebrate and vertebrate animal models as well as iPSC-organoid systems.
Exp Neurobiol 2022;31:1~16
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