Fig. 4. Passive immunization reduces neurodegeneration, gliosis, and inflammation in mThy-1-α-synuclein Tg mice. (A) Representative images of mature neuron staining in the prefrontal cortex and hippocampus. (B, C) Optical density measurements in NeuN-immunopositive areas of the prefrontal cortex and hippocampus. (D) Representative images of astrogliosis staining in the parietal cortex and hippocampal regions. (E, F) Optical density measurements in GFAP-immunopositive areas of the parietal cortex and hippocampus. (G) Representative images of microgliosis staining in the prefrontal cortex and hippocampus. (H, I) Optical density measurements in Iba-1~immunopositive areas of the prefrontal cortex and hippocampus. (J) Representative images of IL-1 β cytokine staining in the hippocampus. (K) Optical density measurements in IL-1β~immunopositive areas of the hippocampus. Scale bar, 200 μm (G) and 100 μm (J). Data are expressed as means±s.e.m. (n=5~6 per group; #p<0.05 vs. WT+3A9 group, *p<0.05 vs. TG+IgG group; one-way ANOVA with two-sided Tukey’s post hoc test). Pfcx, prefrontal cortex; Pacx, parietal cortex; HP, hippocampus.
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