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Fig. 3. Interleukin-13 neutralizing antibody has no effects on neurotoxicity and inflammation in rat striatum in vivo. Animals unilaterally received intrastriatal injection of PBS (A~F, 3 µl) or Interleukin 13 neutralizing antibody (IL-13NA, 1 µg; G~L) as a control. 7 days later, animals were sacrificed, and the coronal sections (40 µm) were selected and processed for immunostaining with neuronal nuclei (NeuN) and Nissl staining (A, B, G, H), GFAP (C, D, I, J) and OX-42 (E, F, K, L). Arrowheads indicate NeuN+ cells merged with Nissl+ cells (NeuN+/Nissl+). (M) Number of NeuN+/Nissl+ cells in the striatum at 7 days after injection. Three animals were used for each experimental group. The results represent mean±SEM. Scale bar, (A, C, E, G, I, K) 100 µm; (B, D, F, H, J, L) 25 µm.
Exp Neurobiol 2022;31:42~53
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