Fig. 3. Immunohistochemical analysis of ionized calcium-binding adapter molecule 1 (Iba1) and glial fibrillary acidic protein (GFAP) in normal control and SCI-induced rats on D7PI. Iba1-positivity in normal (A), SCI+vehicle-treated (B) and SCI+alendronate 1 mg/kg-treated (C) rats. A semi-quantitative analysis showed the reduced activation of microglia in the SCI+alendronate 1 mg/kg-treated group (D). GFAP staining was detected in normal (E), SCI+vehicle-treated (F) and SCI+alendronate 1 mg/kg-treated (G) rats. A semi-quantitative analysis showed a significant decrease in GFAP staining in the SCI+alendronate 1 mg/kg-treated group (H). Scale bars=50 μm. *p<0.05; **p<0.01 vs. normal control. #p<0.05 vs. SCI+vehicle-treated group.
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