Fig. 2. Protective mechanism of autophagy from oxidative stress by ototoxic drugs: The loss of membrane potential due to glutamate agonists increases the ion exchange in the mitochondria resulting in ROS production. Autophagy activation results in autophagosome formation. The damaged mitochondria are recruited to the lysosome by the autophagosome for degradation, thereby reducing the oxidative stress by completing the autophagic flux.
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