Experimental Neurobiology

Fluorescence intensity of SOX2, p-mTOR, and colocalized SOX2-p-mTOR in the Sal, LPS, and LPS+3MA groups

Fluorescence		Sal	LPS	LPS+3MA
SOX2	Area	4,700±423.3	7,077±337.5*	3,874±678.7^##
	Raw intensity (RawIntDen)	904,601±69,004	1.42×10⁶±86,026*	791,341±136,149^##
p-mTOR	Area	9,095±639.1	2,893±510.8*	13,125±1,981^###
	Raw intensity (RawIntDen)	1.961×10⁶±182,704	636,602±120,655*	2.69×10⁶±422,897^###
SOX2+p-mTOR	Area	2,839±55.19	556±18.61***	1,724±279.1^##
	Raw intensity (RawIntDen)	266,093±8,018	54,912±645.2***	153,426±21,742^##

Values are the mean±SEM, n=3 animals per experimental group. *p<0.05, ***p<0.001 vs. Sal group and ^##p<0.01, ^###p<0.001 vs. LPS group in the post hoc Tukey’s multiple range tests. p-mTOR: phospho-mTOR. SOX2: SRY-Box Transcription Factor 2. Sal: saline infusion, LPS: LPS peritoneal infusion (IP) with saline icv infusion, LPS+3MA: LPS (IP) with 3MA (icv). icv: intracerebroventricular infusion. 3MA: 3-Methyladenine.

Exp Neurobiol 2022;31:307~323 https://doi.org/10.5607/en22005