Fig. 2. The increased protein expression of autophagy signaling in the hippocampus induced by LPS administration was prevented by icv infusion of 3MA. Representative gels (inset) and densitometric analysis of the Western blot results showing changes in the expression of (A) Beclin 1, (B) Atg5, (C) Atg12, (D) SQSTM1, (E) LC3B-I, and (F) LC3B-II. Values are the mean±SEM, n=10 to 12 animals per experimental group. *p<0.05, **p<0.01, **p<0.001 in the post hoc Tukey’s multiple range tests. Sal: vehicle infusion, LPS: LPS (IP) with vehicle (icv), LPS+3MA: LPS (IP) infusion with 3MA (icv).
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