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Fig. 6. The LPS-induced increase in SOX2 expression in the hippocampus was reversed by icv infusion of 3MA. (A) Representative immunofluorescence images showing the signals of SOX2 (green) in the hippocampus in the Sal, LPS, and LPS+3MA groups. (B) Representative gels (inset) and densitometric analysis of the Western blot results showing changes in the expression of SOX2. Values are the mean±SEM, n=10-12 animals per experimental group. *p<0.05 in the post hoc Tukey’s multiple range tests. SOX2: SRY-Box Transcription Factor 2. Sal: saline infusion, LPS: LPS peritoneal infusion (IP) with saline icv infusion, LPS+3MA: LPS (IP) with 3MA (icv). icv: intracerebroventricular infusion. 3MA: 3-Methyladenine. Scale bar: 20 µm.
Exp Neurobiol 2022;31:307~323
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