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Fig. 8. The phospho(p)-mTOR signal was primarily in hippocampal neurons, and some SOX2+ cells with p-mTOR+ signals were in the dentate gyrus. Representative immunofluorescence images showing (A) NeuN+ (red)-p-mTOR+ (green), and (B) SOX2+ (red)-p-mTOR+ (green)-DAPI (blue) in the hippocampus in the Sal, LPS, or LPS+3MA groups. DAPI was used to identify the nuclei. Sal: saline infusion, LPS: LPS peritoneal infusion (IP) with saline icv infusion, LPS+3MA: LPS (IP) with 3MA (icv). icv: intracerebroventricular infusion. 3MA: 3-Methyladenine. p-mTOR: phospho-mTOR. SOX2: SRY-box Transcription Factor 2. Scale bar: 20 ┬Ám. Yellow arrowhead: double-labeled cells.
Exp Neurobiol 2022;31:307~323
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