Demographic and clinical characteristics of patients with major depressive disorder and healthy controls.
| Characteristics | MDD (n=101) | HC (n=99) | p-value (t, c2) |
|---|---|---|---|
| Age | 33.47±12.45 | 35.91±13.26 | 0.181 (t=-1.344) |
| Sex (female/male) | 54/47 | 63/36 | 0.146 (chi2=2.130) |
| Education level | |||
| <10 years | 5 | 1 | |
| 10~16 years | 91 | 92 | 0.221 (chi2=2.743) |
| >16 years | 5 | 6 | |
| HDRS-17 score | 16.51±5.79 | 0.60±1.33 | <0.001 (t=26.676) |
| TICV (cm3) | 1,461.43±170.60 | 1,466.94±148.85 | 0.808 (t=-0.243) |
| TAS | 63.23±9.19 | 39.37±5.79 | <0.001 (t=19.852) |
| TAS_Difficulty describing feelings | 17.94±3.63 | 10.06±3.21 | <0.001 (t=16.252) |
| TAS_Difficulty identifying feelings | 22.91±5.63 | 10.71±3.52 | <0.001 (t=18.349) |
| TAS_Externaly-oriented thinking | 22.38±3.76 | 18.61±3.66 | <0.001 (t=7.185) |
| Medication, n | |||
| Antidepressants | |||
| SSRI | 13 | NA | |
| SNRI | 3 | ||
| NDRI | 1 | ||
| NaSSA | 1 | ||
| Etc | 3 | ||
| Combination of AD | 34 | ||
| Antipsychotics | |||
| AP | 16 | ||
| Combination of AP | 2 |
Data are mean±standard deviation for age, HDRS-17 scores, illness duration, and TICV. p-values for distribution of sex and education level were obtained using a chi-squared test. P-values for comparisons of age, HDRS scores, and TICV were obtained using an independent t-test.
HCs, healthy controls; MDD, Major depressive disorder; HDRS-17, 17-item Hamilton Depression Rating Scale; TICV, total intracranial cavity volume; SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin and norepinephrine reuptake inhibitor; NDRI, norepinephrine-dopamine reuptake inhibitor; NaSSA, noradrenergic and specific serotonergic antidepressant; Combination of AD, combinations of two or more types of antidepressant; APs, antipsychotics; ADs, antidepressants.