Demographic and clinical data for patients with major depressive disorder and healthy controls
| MDD (n=46) | NML (n=23) | t or χ2 | p | |
|---|---|---|---|---|
| Age, years | 36.07 (14.34) | 36.78 (14.42) | 0.196 | 0.942 |
| Sex (male/female) | 13/33 | 5/18 | 0.772 | |
| Educational (years) | 13.87 (2.90) | 16.09 (1.80) | 3.874 | <0.001 |
| HRSD scores | 15.98 (5.35) | 1.26 (2.12) | -16.299 | <0.001 |
| ICV | 1,406.95 (120.14) | 1,467.89 (143.68) | 1.859 | 0.067 |
| Duration of illness (months) | 109.09 (100.03) | |||
| Family History of mood disorder | 3 (14.2) | |||
| Past mood episodes (times) | 3.1 (2.1) | |||
| Medication | ||||
| SSRI | 8 | n/a | ||
| SNRI | 0 | n/a | ||
| NDRI | 2 | n/a | ||
| NaSSA | 2 | n/a | ||
| SSRE | 1 | n/a | ||
| Combination of AD | 28 | n/a | ||
| Lithium | 0 | n/a | ||
| AED | 5 | n/a | ||
| Lithium+AED | 0 | n/a | ||
| AED+AED | 0 | n/a | ||
| AP | 7 | n/a | ||
| Combination of AP | 4 | n/a |
All data are represented as mean (SD) or number (%). MDD: patients with major depressive disorder, NML: healthy controls, HRSD: Hamilton. Rating Scale for Depression, ICV: Intracranial volume. *p<0.05. Medication: AD, antidepressants; AED, Anti-epileptic drugs; AP, Antipsychotics; Combination of AD, Combination of two or more types of antidepressants; NaSSA, Noradrenergic and Specific Serotonergic Antidepressant; NDRI, Norepinephrine-Dopamine Reuptake Inhibitor; SNRI, Serotonin and Norepinephrine Reuptake Inhibitor; SSRI, Selective Serotonin Reuptake Inhibitor.