Fig. 5. Understanding input–output (I-O) plasticity during the LTD by the integration of synaptic plasticity in the TA-CA1 synapses and the E-S potentiation. Activation of the MAP kinase (MAPK) at the TA-CA1 synapse could only be activated by the simultaneous activation of the mGluR5 and two types of dopamine receptors. Activation of either the D1 receptor or D2 receptor alone may induce LTP by increasing postsynaptic AMPA conductance; however, a potential retrograde signaling, which would influence the presynaptic release, would require the converging activation of MAPKs to induce LTD. Independent from the synaptic plasticity, the activation of the D1 receptors would contribute to the PIE of the CA1-PCs by inhibiting the K+ current.
© Exp Neurobiol
