Fig. 3. NE increases spontaneous excitatory synaptic transmission onto LSdSst neurons. (A) Top, schematic of Cre-dependent expression of eYFP and patch-clamp whole-cell recording from LSdSst neurons. Bottom, representative differential interference contrast (DIC) and fluorescence images of a LSdSst neuron expressing eYFP during recording. (B~D) Bath application of 10 μM NE increased mEPSC amplitude without affecting mEPSC frequency. Representative traces (B) and group data for mEPSC amplitude (n=9, p=0.039) (C) and frequency (n=9, p=0.570) (D). (E~G) Application of 100 nM corticosterone did not affect either mEPSC amplitude (n=7, p=0.297) (F) or frequency (n=7, p=0.938) (G). Scale bar, 10 pA, 1 s. Data are represented as mean±s.e.m. Asterisks indicate significance levels for comparisons using Wilcoxon rank-sum test (*p<0.05).
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