Experimental Neurobiology

Top overexpressed biological pathways obtained from KEGG Mapper

KEGG pathway	Genes
Metabolic pathway	ALDH1L1, PDE10A, DPYD, PISD, GPX6, GBE1, PIK3C3, UGT2A2, NMNAT1, TK2, HYAL2, B3GALNT1
Pathways of neurodegeneration - multiple diseases	GPX6, APP, ITPR1, PIK2C3, ZFYVE1
Ras signaling pathway	AKT1, FGF1, GNG7, PAK6, ZAP70
Apelin signaling pathway	EGR1, AKT1, GNG7, ITPR1, PIK3C3
Autophagy	AKT1, ITPR1, PIK3C3, ZFYVE1
cAMP signaling pathway	PDE10A, ADRB1, AKT1, GNAS
Serotonergic synapse	GNAS, GNG7, APP, ITPR1
Calcium signaling pathway	ADRB1, FGF1, GNAS, ITPR1

ALDH1L1 , aldehyde dehydrogenase 1 family member L1 ; PDE10A , phosphodiesterase 10A ; DPYD , dihydropyrimidine dehydrogenase ; PISD , phosphatidylserine decarboxylase ; GPX6 , glutathione peroxidase 6 ; GBE1 , 1,4-alpha-glucan branching enzyme 1 ; PIK3C3 , phosphatidylinositol 3-kinase catalytic subunit type 3 ; UGT2A2 , UDP glucuronosyltransferase family 2 member A2 ; NMNAT1 , nicotinamide nucleotide adenylyltransferase 1 ; TK2 , thymidine kinase 2 ; HYAL2 , hyaluronidase 2 ; B3GALNT1 , beta-1,3-N-acetylgalactosaminyltransferase ; AKT1 , AKT serine/threonine kinase 1 ; FGF1 , fibroblast growth factor 1 ; GNG7 , G protein subunit gamma 7 ; PAK6 , p21 (RAC1) activated kinase 6 ; ZAP70 , zeta chain of T cell receptor associated protein kinase 70 ; GPX6 , glutathione peroxidase 6 ; APP , amyloid beta precursor protein ; ITPR1 , inositol 1,4,5-trisphosphate receptor type 1 ; ZFYVE1 , zinc finger FYVE-type containing 1 ; EGR1 , early growth response 1 ; PDE10A , phosphodiesterase 10A ; ADRB1 , adrenoceptor beta 1 ; GNAS , GNAS complex locus.

Exp Neurobiol 2023;32:119~132 https://doi.org/10.5607/en22035