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Fig. 3. Isoform 1 and 2 have similar voltage- and temperature-dependency. (A) Representative traces of steady-state currents of isoform 1 and 2 with 0, 1, and 5 μM [Ca2+]i in 1 s duration voltage steps from -100 mV to +100 mV with 20 mV steps. The end of the step currents was analyzed (in black and blue circles). (B) The current–voltage relationship at the end of the voltage steps at room temperature (26°C). (C) The rectification of isoforms 1 and 2 at 26°C. The rectification index was calculated by the average ratio between current at +100 mV and -100 mV at 5 μM intracellular calcium. (D) The current–voltage relationship at 36°C. (E) The temperature-dependency of isoforms 1 and 2. The temperature-dependency was calculated by the ratio of currents at 26°C and 36°C at 5 μM [Ca2+]i. Error bars indicate SEM. ns, not significant.
Exp Neurobiol 2023;32:133~146
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