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Fig. 5. Comparisons of cavity structure of ANO2. (A, B) The cavity of the ANO2 channel was subdivided into three parts: the calcium-binding space (in brown), the remaining space (in purple), and the entrance space (in green). Ca2+ located in the calcium-binding sites is shown in red. The calculated volumes of the cavity are shown in the table. (C, D) Enlarged view of the structure near the cavity entrance space of ANO2 isoforms 1 and 2, respectively. The residues of 479ERSQ are depicted in orange and E477 is in green. The carbon atoms are shown in yellow, oxygen atoms are in magenta, and nitrogen atoms are in blue. (E, F) View of structures from the intracellular side of ANO2 isoforms 1 and 2, respectively.
Exp Neurobiol 2023;32:133~146
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