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Fig. 1. Psen2 N141I mutation alters rhythmic expression patterns of clock genes in microglia. (A~J) Comparison of transcript abundance of representative circadian clock genes at different times after synchronization during 24 h (A, Nr1d1; B, Nr1d2; C, Arntl; D, Clock; E, Cry; F, Rora; G, Per1; H, Per2; I, Dbp; J, Csnk1a1). For RNA extraction, microglia were collected every 4 h after 2 h synchronization by dexamethasone (DEX, 100 nM) treatment (n=4). mRNA levels were normalized to Actb. Data are meanĀ±SEM.
Exp Neurobiol 2023;32:259~270
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