Fig. 2. Psen2 N141I mutation alters rhythmic expression patterns of clock genes in astrocytes and BMDM. (A~F) Comparison of transcript abundance of representative circadian clock genes at different times after synchronization during 24 h in primary astrocytes (A, Nr1d1; B, Arntl; C, Clock; D, Per1; E, Per2; F, Cry) and (G~L) BMDM (G, Nr1d1; H, Arntl; I, Clock; J, Per1; K, Per2; L, Cry). For RNA extraction, cells were collected every 4 h after 2 h synchronization by dexamethasone (DEX, 100 nM) treatment (n=3). mRNA levels were normalized to Actb. Data are mean±SEM.
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