Fig. 5. Psen2 N141I mutation does not down-regulate REV-ERBα or alter the central clock. (A) Relative mRNA expression levels of Nr1d1 in the suprachiasmatic nucleus (SCN) region from WT or Psen2N14I/+ mice (n=3). mRNA levels were normalized to Actb. (B) Representative results of bioluminescence recordings in the SCN slices from Per2::Luc;Psen2+/+ (WT) or Per2::Luc;Psen2N141I/+ mice (KI/+). (C) All recordings of SCN slices (n=8) were used to analyze the circadian period and amplitude. Data are mean±SEM.
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