Fig. 6. Psen2 N141I mutation does not affect circadian behavior and physiology. (A) Representative actograms of locomotor activity of WT and Psen2N141I/+ (KI/+) mice. The periods of constant darkness were revealed by a gray background. Mice were exposed to 12 h:12 h light/dark cycles (LD, 14 days), as indicated by the empty and filled bars shown above, followed by constant darkness (DD, 14 days; gray background). (B) Periodograms for locomotor activity under constant darkness. The number in the plot shows the average value (h) of peaks of each genotype. (23.9±2.275 h in WT and 23.9±0.212 h in KI/+; n=8). Gray line: periodogram for individual mouse; black line, average of each animal; red line, significance at p<0.001 using chi-square (Qp) statistics. (C) Total locomotor activity of WT and Psen2N141I/+ (KI/+) mice. Average activity was counted under 12 h:12 h light/dark cycles (LD) and constant darkness (DD). (D) Representative actograms of body temperature in WT and KI/+ mice. (E) Periodograms for body temperature under constant darkness (23.9±0.0025 h in WT and 23.8±0.160 h in KI/+; n=8). Gray line: periodogram for individual mouse; black line, average of each animal; red line, significance at p<0.001 using chi-square (Qp) statistics.
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