Fig. 1. Task schematic for the delayed-response task and behavioral outcomes (A) Task schematic of the tactile delayed-response task. A pole was touched to an anterior or a posterior part of the whisker for 1.3 s (sample period), followed by a delay period of 1.3 s. In the response period, the mice licked to the left if the pole touched an anterior part of the whisker. Conversely, if the pole touched a posterior part of the whisker, mice licked to the right. (B) In the auditory delayed-response task, instead of tactile stimuli, auditory stimuli were presented. During a 1.15 s sample period, a 12 kHz or 3 kHz sound was presented, guiding the mice to lick to the left in case of a high frequency or lick to the right in case of a low frequency. After a delay of 2 s, the response period was initiated. (C) Possible behavioral outcomes in the perceptual delayed-response task depending on the match between the sensory stimulus (anterior vs. posterior in the tactile delayed-response task; low vs. high frequency in the auditory delayed-response task) and licking direction (left vs. right). Hit Right (HR): mice correctly licked to right in response to the posterior cue (or low frequency). Hit Left (HL): mice correctly licked to left in response to the anterior cue (or high frequency). Error Right (ER): mice incorrectly licked to left in response to the posterior cue (or low frequency). Error Left (EL): mice incorrectly licked to right in response to the anterior cue (or high frequency). (D) Decision accuracy in the tactile and auditory delayed-response tasks. Each line indicates the decision accuracy of a session. There was no significant difference in decision accuracy between the posterior and anterior cues (or low vs. high frequency) (two-sided Wilcoxon rank sum test, p>0.1).
© Exp Neurobiol
