Fig. 3. Only infralimbic pyramidal neurons in layer 2/3 were altered after tBCCAO. (A) Schematic figure of layer 2/3 neurons in the IL. (B) Representative traces from depolarizing and hyperpolarizing current injection protocol. (C) The firing frequency was significantly reduced in the tBCCAO group (sham=18, tBCCAO=17, p<0.001). (D) The rheobase current of tBCCAO group was considerably higher than that of sham group (p=0.017). (E) Sag voltage of tBCCAO group was comparable to those of sham group (sham=13, tBCCAO=15, p=0.428). (F) The input resistance was significantly decreased in the tBCCAO group (p=0.006). (G) Schematic figure of layer 5 neurons in the IL. (H) Representative traces from depolarizing and hyperpolarizing current injection protocol. In IL layer 5 neurons, (I) firing frequency and (J) rheobase current of tBCCAO group were comparable to those of sham group (sham=13, tBCCAO=20; firing frequency, p=0.090; rheobase current, p=0.209). (K) The Sag voltage and (L) input resistance of tBCCAO group were comparable to those of sham group (sham=13, tBCCAO=18; sag voltage, p=0.187; input resistance, p=0.487). *p<0.05, **p<0.01, ***p<0.001.
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