Fig. 3. Dendrograms exhibiting GC-induced up- or downregulated genes and the reversion of their altered expression by
Lpc-EV in HT22 cells. (A) A dendrogram showing the expression patterns of the 135 genes of Cluster 5 in Quadrant A. The heatmap highlighted the up-regulation of the genes by GC and the reversal of their altered expression by
Lpc-EV in duplicate sample groups. Red and blue represent up-regulation and down-regulation, respectively, in the heatmap. Expression levels, log2 values. The stress signature genes
Mkp1 (Dusp1) and
Fkbp5 were marked. See also
Supplemental Table S1 and
S2. (B, C) Dendrograms showing the expression patterns of the 101 genes in Cluster 3 (B) and the 99 genes in Cluster 4 (C) in Quadrant D. The heatmap exhibiting GC-dependent downregulation and
Lpc-EV-induced reversion of their altered expression in duplicate sample groups. Red and blue represent up-regulation and down-regulation, respectively, as above. Expression levels, log2 values.
Ngf,
Vgefa, and
Mecp2 were marked. See also
Supplemental Table S1 and
S3.
