Fig. 4. Lpc-EV treatment counteracted GC-induced altered expression of epigenetic factors in HT22 cells. (A, B) Expression levels of Cbp, p300, Hdac1, Hdac2, Hdac3, Sirt1, and Sirt7 (A), and Kdm4a, Kdm4b, Suv39h1, and Setdb1 (B) in HT22 cells treated for 24 h with GC (400 ng/ml) or GC plus Lpc-EV (10 μg/ml). HATs, Histone Acetyltransferases; HDACs, Histone Deacetylases; HMTs, Histone methyltransferases; HDMTs, histone demethylases. (C, D) Expression levels of Cbp, p300, Hdac1, Hdac2, Hdac3, Sirt1, and Sirt7 (C), and Kdm4a, Kdm4b, Suv39h1, and Setdb1 (D) in HT22 cells treated for 24 h with GC (400 ng/ml), GC plus Lpc-EV (10 μg/ml) and control-siRNA, or GC plus Lpc-EV and Mecp2-siRNA. Data are presented as the mean±SEM (n=6~8). *p<.05; **p<.01 (one-way ANOVA followed by Newman-Keuls post hoc test, and two-way ANOVA followed by Bonferroni post hoc test).
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